premature ovarian failure (pof) is a heterogeneous syndrome with several causative factors. autoimmune mechanisms are involved in pathogenesis of 4-30 % of pof cases. the present review focuses on the role of autoimmunity in the pathophysiology of pof. the evidences for an autoimmune etiology are: demonstration of ovarian autoantibodies, the presence of lymphocytic oophoritis, and association w...

objective: to evaluate whether systemic inflammatory markers (neutrophil to lymphocyte ratio (nlr), platelet to lymphocyte ratio (plr) and red blood cell distribution width (rdw) to platelet ratio (rpr)) can be used as reliable markers for the diagnosis of premature ovarian insufficiency (poi) and to determine if there is a relationship between these markers and follicle stimulating hormone (fs...

Zusammenfassung Die prämature Ovarialinsuffizienz (POI) ist durch eine Amenorrhö und erhöhte FSH(Follikelstimulierendes Hormon)-Werte gekennzeichnet. Sie kann spontan auftreten, chronische oder Autoimmunerkrankungen, genetisch iatrogen gonadotoxische operative Therapie bedingt sein. Zur Diagnostik gehören die Bestimmung der jeweiligen Laborparameter, Sonographie, Knochendichtemessung genetische...

OBJECTIVE To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls. METHODS A 5mL sample of peripheral blood was collected from all study participants in an EDTA tube and was used for DNA extraction. For the patient group, 5mL of blood were also collected in a ...